Diabetes drug improves glucose control without increasing risk of hypoglycemia, study suggests

ScienceDaily (Feb. 27, 2012) ? Too high? Too low? Only about half of those with type 2 diabetes have their blood sugar levels on target, but a new drug shows promise in managing glucose levels.? TAK-875 works by boosting the release of insulin from pancreatic B cells, but only when diabetics need it most ? such as when glucose and fatty acids rise in the blood after a meal.

TAK-875, a new treatment for type 2 diabetes, improves blood sugar control and is equally effective as glimepiride, but has a significantly lower risk of creating a dangerous drop in blood sugar, called hypoglycemia, according to a new study.

The results of the phase 2 randomized trial were published in The Lancet.

Type 2 diabetes is the most common form of diabetes accounting for 90 percent of the 150 million people in the United States currently living with the disease. It is primarily caused by a lack of response to insulin which leads to high blood sugar and a variety of chronic conditions.

Free fatty acid receptor 1, also known as G protein-coupled receptor 40, or GPR40, plays a vital role in stimulating and regulating the production of insulin.

It works by boosting the release of insulin from pancreatic ?-cells when glucose and fatty acids rise in the blood, such as after a meal, which results in a fall in blood glucose levels. Drugs that activate the FFAR1 receptor have the potential to help diabetics release more insulin and improve control of blood glucose levels.

TAK-875 is a novel oral medication designed to enhance insulin secretion in a glucose-dependent manner, which means that it has no effect on insulin secretion when glucose levels are normal, and as such has the potential to improve the control of blood sugar levels without the risk of hypoglycemia.

In the study, Charles Burant, M.D., Ph.D., professor of internal medicine at the University of Michigan Health System, and colleagues randomly assigned 426 patients with type 2 diabetes who were not achieving adequate glucose control through diet, exercise or metformin treatment to one of five doses of TAK-875, a placebo, or glimepiride, a conventional diabetes treatment. The primary outcome was change in hemogloblin A1c from the start of the study.

At 12 weeks, all doses of TAK-875 resulted in significant drops in HbA1c compared with placebo, a similar reduction occurred in patients given glimepiride.

At a TAK-875 dose of 25 mg or higher, about twice as many patients (33 to 48 percent) reached the American Diabetics Association target of HbA1c less than 7 percent within 12 weeks, compared with placebo (19 percent) and was similar to glimepiride (40 percent).

TAK-875 was generally well-tolerated. The incidence of hypoglycaemia was significantly lower for all doses of TAK-875 compared with glimepiride (2 percent compared to 19 percent), and was similar to placebo which was 2 percent.

The overall incidence of treatment-related side effects was similar for the TAK-875 groups and placebo groups (49 percent; all TAK-875 groups vs 48 percent), but higher in the glimepiride group (61 percent) because of the increased risk of hypoglycemia.

The authors say: "In view of the frequent hypoglycaemia after treatment with sulfonylureas,the low-risk of hypoglycemia after treatment with TAK-875 suggests that there may be therapeutic advantage of targeting FFAR1 in treating people with type 2 diabetes." They conclude:"We are truly excited about the potential of TAK-875 and are eager to conduct larger trials to find out how well this drug works, how safe it is and what its place is in the treatment of diabetes.

"TAK-875 significantly improved glycaemic control in patients with type 2 diabetes with minimum risk of hypoglycemia. The results show that activation of FFAR1 is a viable therapeutic target for treatment of type 2 diabetes," authors say.

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The above story is reprinted from materials provided by University of Michigan Health System, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Charles F Burant, Prabhakar Viswanathan, John Marcinak, Charlie Cao, Majid Vakilynejad, Benhuai Xie, Eckhard Leifke. TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. The Lancet, 2012; DOI: 10.1016/S0140-6736(11)61879-5

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2012/02/120227093759.htm

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Use Of Physical Therapy Tables In Rehabilitative Therapy Software ...

As a physical therapist, you will take a look at people clinical histories, decide treatment schemes and look at people stage of progress. The strategies you use will aid people raise their mobility with decreased ache. You can aid people avoid losing mobility or raise mobility missing because of injuries such as uses up, amputation, arthritis or defects such as cerebral palsy or spina bifida. You could aid people execute physical exercise to boost their scenario or teach them to use units and tools to support in mobility.

A physical therapist does not purpose alone, he wants an assistant. This assistant is called as a physical therapist assistant or PTA. Physical Therapist Assistant Salary Obtaining the profession as a PTA does not only have a fantastic shell out to allow you reside easily, but it is also fulfilling to your element considering the fact that it allows you aid other people in slowly and gradually recovering from the problem they are struggling, so permitting them reside independently. The typical annual salary of a physical therapy assistant is from forty,000-sixty,000.

Currently there are several offices in the United States that do have chiropractors and physical therapists performing jointly. They are more equipped to supply hands on diagnoses of situations and what study course of treatments should be followed. Functioning jointly they can reduce ache and boost a people mobility.

The physical therapy act also plainly indicates the requirements for practising physical therapy, such as the right to operate only when a person is competently licensed to do so in his or her state. No person is also permitted to declare to be a physical counselor or use its phrases or any of its abbreviations so as to indicate that the human being is a lawful physical therapist until he is physical therapist accredited by the state government.

Because of to their extreme exercise regimen, it is popular for skilled athletes to visit physical therapists who specialize in injuries that consequence from particular fitness and skilled athletics. Even so, athletics physical therapists also deal with people from all professions and walks of living. Very similar to standard physical therapists, athletics physical therapists are worried with creating positive that their people are equipped to resume their every day activities as a result of physical exercise and other treatment strategies.

This kind of therapy can be easily availed at hospitals, clinics or fitness centers. You have to have to make positive to get a fantastic physical therapist you need to look at individuals suggested by close friends and relatives. Health and fitness insurance organizations and doctors also supply a record of fantastic physiotherapists. You initial have to have to look into if the therapist is capable and has the vital diploma. physical therapy school Faulty therapy can be harmful and lead to physical situations and result in the patient to develop into immobile. So be cautious when deciding upon a fantastic physical therapist.

Physical therapists are lucky to have the option to operate in so several distinct configurations. An really popular facility for physical therapists to look for work is a hospital. physical therapy doctoral programs Because there are so several form of treatments for distinct areas of the body, physical therapy will get subdivided into distinct groups in purchase to assure that every person is receiving the most powerful treatment achievable to suit their wants.

Source: http://indianamustangandburro.com/use-of-physical-therapy-tables-in-rehabilitative-therapy-software-programs/1783/

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PlayStation Vita Facebook app pulled for repairs, Sony blames house of Zuckerberg

After a short, two day stint on Sony's next generation portable, Facebook's Vita app has been pulled from the PSN store. According to a post on the official PlayStation Forums (EU), users were encountering an error code while trying to log into the popular social network, forcing them to close the application. Community team leader PadPoet says the error is a "Facebook specific issue (on their side)," and that the two outfits are working on a solution. "We will announce further details when ready," a Sony rep told Joystiq. Hopefully the app will make a triumphant return shortly, though it's absence doesn't make cripple the handheld's social aspiration's completely -- after all, there's always Twitter.

PlayStation Vita Facebook app pulled for repairs, Sony blames house of Zuckerberg originally appeared on Engadget on Fri, 24 Feb 2012 17:56:00 EDT. Please see our terms for use of feeds.

Permalink Joystiq  |  PlayStation Forum (EU)  | Email this | Comments

Source: http://www.engadget.com/2012/02/24/playstation-vita-facebook-app-pulled-for-repairs-sony-blames-ho/

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S&P 500 on track to end at four-year high (Reuters)

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Reuters - The S&P 500 was little changed on Friday but on track to finish at four-year highs after upbeat reports on housing and consumer sentiment.

Source: http://us.rd.yahoo.com/dailynews/rss/stocks/*http%3A//news.yahoo.com/s/nm/20120224/bs_nm/us_markets_stocks

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Strange Phobias

Phobia is defined as an intense fear of any particular object, place or situation caused by various biological and environmental factors. Emotional traumas and unpleasant situations like death of a relative or failure in work are the most common factors responsible for developing phobia. A phobic person often show signs of nausea, anxiety, sweating, panic attack and breathlessness.

Every individual experiences a blend of negative and positive experiences at some or the other stage of life. All these experiences are linked to the amygdala and hippocampus areas of the brain through the nerves. The nervous system regulates the body?s response to negative and positive experiences of life and stores them in the brain memory. Good memories of positive experiences often come out as laughter and happiness whereas bad moments from unpleasant and negative situations come out as fear, anxiety or elevated stress.

In case of any unpleasant situation, a person receives a shock that gradually activates the NMDA receptor, a brain receptor responsible for excitatory neurotransmission. These molecules further produce specific physiological effects in the cell that gets triggered when the shock reaches the brain. Over a period of time, these NMDA receptors leave their imprints on brain cells that are further transformed to phobias.

There is an endless list of phobia that greatly influences the physical and mental well being of the individual. The list includes serious phobias, funny phobias, unusual phobias and various other strange facts.

Strange phobia is an excessive and unreasonable fear of something strange, something that no body can even imagine. These phobias often lead to elevated stress and sense of impending death. Following is the list of phobias:

? Allodaxaphobia ? Fear of the opinions of other people. People suffering from this phobia avoid going for debates and discussions as they can?t bear opinions of any other people.

? Barophobia ? Fear of gravity. It?s so strange to imagine that there are people who have the fear of gravity.

? Chromophobia ? Fear of colors. People suffering from this phobia tend to stay away from anything colorful.

? Dextrophobia ? Fear of objects at the right side of the body.

? Euphobia ? Fear of hearing good news. Many people have experienced so many bad moments in life that they fear good news and good moments of life.

? Francophobia ? Fear of France or French culture. Many people fear foreign culture and language.

? Genuphobia ? Fear of knees. It?s again a very strange and weird fear.

? Hippopotomonstrosesquippedaliophobia ? Fear of long words. People suffering from this phobia tend to be brief in their talks as they fear long words.

? Ideophobia ? Fear of ideas.

? Japanophobia ? Fear of the Japanese. People, who have experienced some unpleasant situation in Japan or heard some negativity of Japanese, develop a fear for them.

? Optophobia ? Fear of opening one?s eyes. What a weird fear? Few have this fear because they feel that if they open their eyes, they will see something bad happening around.

? Plutophobia ? Fear of wealth. In today?s corporate world, how can one fear wealth? Everyone is becoming a machine to earn more and more wealth but there are people who don?t want to become wealthy as they fear wealth.

? Selenophobia ? Fear of the moon. Few of the people don?t go out during night as they fear moon and moonlight.

? Uranophobia ? Fear of heaven. Heaven is a place that everybody wants to go but yet they are people who have the fear of heaven.

? Cacophobia: Fear of ugliness. These people react strangely to ugly characters, people or any other strange and ugly looking items.

? Dendrophobia: Fear of trees. These people are afraid of any place where there are ample of trees so they avoid going to forests, hiking trails and parks.

? Telephonophobia: Fear of telephones. Even though telephones have become the fastest means of communication today, there are many people who will avoid using telephones.

? Aritmophobia: Fear of numbers. These people avoid learning any financial issues, prices and other activities related to numbers.

? Heliophobia: Fear of the sun. The fear of sun is really a weird phobia but no doubt many people have this fear and these people avoid going to the beach, sitting outside, or any other activities where they are exposed to sunlight.

Source: http://www.a1article.net/health-and-fitness/strange-phobias-4750.html

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Real Estate Agents Calgary

Initially, have a discuss with a great deal of agents. This will assist that you hire the most effective one of them. You could potentially choose the best agent, who makes your work and life easier. Additionally it is essential to have a good understanding with your realtors. Only after that your work will be reduced and they'd take your specific needs into consideration, thereby giving an answer to your desires along with. Secondly, it is a finer choice to hire a highly skilled Calgary realtor, because they have more idea about the niche rates and trends. Hiring experienced realtors could possibly be costly, nevertheless they would bring you the hottest deal thus it is strongly suggested to go for experienced agents than other realtors. There are tons of realtors in Calgary who promise in plenty relating to firms but finally do not continue their word. Hence look for a real estate agent with references, so that you could consult those reference persons to obtain a concept with regards to the particular real estate property agency. If your realtor has a big list of references it shows that you have selected a good realtor.

First of all it is best to check out a true estate market. Ensure that your agent well knows about market rates and satisfy your requirements. Don't give preference to individuals Calgary realtors who first smiles at you. Here is the common mistake that a majority of of individuals in Calgary do. Each goes for that agents whom they've got met first. Folks don't even have a tendency to test regardless of if the realtor features a good knowledge in marketing. Check each one of the realtors thoroughly and make certain they talk to you honestly. A superb realtor gives you the names of these top customers and may feel happy and proud to make you possess a talk to those clients.

Real Estate Agents Calgary

Tags: good knowledge, niche rates, single person

Source: http://www.onlinerealestateguide.org/real-estate-agents-calgary/

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Video: Poll: Romney, Santorum tied in Michigan

'American Idol' reveals 14 of 24 semifinalists

??If your favorite singer is a woman whose fate hasn?t been revealed yet, you may be in trouble. If it?s a man you?re worried about, you have a better shot. And if you?re cheering for Adam Brock, you really, really hate the show right now.

Source: http://www.msnbc.msn.com/id/3036697/vp/46488163#46488163

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White House unveils plan to protect online privacy (Reuters)

[unable to retrieve full-text content]Reuters - The White House on Thursday proposed a "bill of rights" that would give consumers greater online privacy protection and could eventually give the government greater powers to police Internet firms such as Google Inc and Facebook.

Source: http://us.rd.yahoo.com/dailynews/rss/tech/*http%3A//news.yahoo.com/s/nm/20120223/wr_nm/us_privacy_online

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Merriman Park hosts Health and Fitness Fair | Advocate Magazine

Merriman Park students and their families learned that being healthy can be fun when they attended the MPE Health and Fitness Fair in January. PTA volunteers recruited the experts, including the Tooth Fairy to discuss dental health, LH?s Janie Christy to teach heart-healthy dance steps and Sparky the Fire Dog to promote fire safety.

Families were reminded that February is American Heart Month, and the Zumba instructor from the White Rock YMCA shared a few moves. Friendly folks from CrossFit and the LH YMCA were also on hand to encourage kids and their parents to exercise and eat healthy.

?We are so fortunate to have so many wonderful businesses and individuals in Lake Highlands who care about the future of our children,? said Liz Kluever, VP of Programs for the MPE PTA. ?By teaching the kids about safety and staying healthy, they are providing them with the tools for a wonderful future.?

The following also provided activities and information: Lake Highlands Soccer Association, Coach Brooks, Dallas Police Department, Dallas Fire and Rescue, EPA, Texas Lice Squad, Dolphin Swim School, Janie Christy School of Dance, Children?s Dental Care, Kelley Huebner on Car Seat Safety, Play Tri, Spring Valley Athletic Association, American Heart Association, Poison Control, Juvenile Diabetes Research Foundation, CHIPS, Medicaid, Smoothie Factory and Donald Wright with Gilchrist and Company.

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Source: http://lakehighlands.advocatemag.com/2012/02/merriman-park-hosts-health-and-fitness-fair/

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Equine Supplements And Acid Reflux Disease In Baby: Keeping ...

[unable to retrieve full-text content]Equine Supplements And Acid Reflux Disease In Baby: Keeping Your Child Protected. New Health And Fitness.Org - Health Information You Can Use. Equine supplements could prevent acid reflux in your horses. For humans ...

Source: http://newhealthandfitness.org/2012/02/20/equine-supplements-and-acid-reflux-disease-in-baby-keeping-your-child-protected/

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Personal Finance Software ? Which One is the Greatest? : USCASCA

Posted on | February 20, 2012 | Comments Off

The personal finance software you use can be an important decision, as finding a good program can allow you to get a handle on your finances. Some of these software programs are designed to help you with your budget, others can do more complicated things like guide your investment strategies. The personal finance software considerations that we?ll be talking about below can help you decide what kind of program is best for you.

When you choose personal finance software, you have to make sure you?re getting something that has all the features you require. However, it?s equally important that you can easily install and learn how to use it. You may find a more advanced program is more suited for you if you have some experience with financial programs and other technology. However, if you want something that?s user friendly and simple to set up, make sure you read the reviews on any software you?re considering to make sure it fits this category. Because no matter how good a software is, it is worthless if you can?t use it.

If you would like to be able to access your software anywhere simply by logging onto the internet then Mvelopes Personal Budgeting system is for you. The focus of this software is budgeting and helping you reduce your expenses. By identifying all of your financial transactions Mvelopes helps you to determine where you can save money. This web based tool is recommended if you mainly want software that helps you manage your budget. However, if you need a program with advanced features for tracking your investments, you?d be better off with another application such as Quicken or Microsoft Money. No question, we are just getting started with all that can be acknowledged about http://www.esavv.com/.

If you primarily use a Macintosh, iBank 4 is one of the personal finance software programs to take into account. This is an idiot-proof program that a variety of Mac users see are beneficial for keeping track of their finances. You can effortlessly stay on top of all your account balances, and also observe your investments. It lets you import transactions from other programs, such as Quicken for Mac, and also to export to TurboTax to file your taxes. It provides you with a free 30 day trial that includes support, so you can sample it for a whole month before determining if you?d like to keep it. If you wish to carry on operating it, it has a nice price of about $60. iBank 4 is a good choice if you use a Mac and want a finance program with a wide variety of helpful features. If you desire to obtain optimal personal finance software, you need to ponder over your requirements, such as the kind of operating system you use, whether you favor an Internet service or downloadable software and which characteristics are essential to you. Hopefully this article has given you some useful insights into the types of personal finance software that?s currently available. If you select the optimal program, you?ll come to find that it?s a lot easier to keep track of your money.

Comments

Source: http://uscasca.com/?p=7304

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Euro Debt Crisis Could Cripple U.S. Business Travel- Financial Eyes ...

The economic climate abroad has potentially severe ramifications to U.S. business travel as owners lose interest in European business opportunities.

According to a new report by the Global Business Travel Association Foundation (GBTA), if the European debt crisis deteriorates any further it could have a significantly damaging impact on U.S. business travel, which in turn could greatly impede the economic recovery in the States that?s just now seeing progress.

The U.S. business travel industry has seen considerable gains over the past three years, which Michael W. McCormick, executive director and COO of the GBTA, attributes to the growth of outbound international travel. Last year alone saw business travel spending up 7.6 percent to $251.9 billion.

However, the current economic condition in Europe could cause business travel from the U.S. to Europe to pull back, resulting in a possible slump for top-line growth that?s been fueled by ?putting people on the road to find new business opportunities.? Not to mention the Euro slid to a one-month low earlier this week after Moody?s Investors Service put several European financial firms up for review, spelling bad news for the European banking system, as well as outbound international travel.

?There?s a strong correlation between business travel growth as a leading indicator for the overall health of the economy and for employment figures here in the U.S.,? McCormick says. ?If there?s not a speedy resolution to the European debt crisis, then what we could see is a domino effect that could reach across the waters and start to have a deep effect on the economy in the U.S.?

How deep of an effect? The GBTA?s report paints three possible scenarios:

• Baseline/Current Scenario: The situation in Europe reaches a point of moderate stability, with continued growth in U.S. business travel reaching $263.5 and $277.3 billion in 2012 and 2013, respectively.
• Moderate Scenario: A drawn-out crisis causes business travel to plateau and eventually decline by $40 billion or 7 percent between 2012 and 2013.
• Severe Scenario: Far-reaching defaults, bank failures, and possibly a dissolved European Union would cause a sharp plummet in business travel spending by as much as $88 billion or 16 percent between 2012 and 2013.

With the frangible European crisis far from being resolved, McCormick fears a ?very concerning environment? is on the immediate horizon. ?Right now we?re seeing a 25 percent chance of moving to a moderate scenario and a 10 percent chance of moving to a more severe scenario?those are, unfortunately, very significant odds,? he says.

Despite the ubiquitous headlines that depict a less than favorable view of the crisis abroad, not everyone in the business travel industry is worried just yet. ?Clearly clients are concerned with what trends might exist and what might be happening with the European crisis, but we haven?t had anyone say they want to modify their travel program in any way,? says Brian Hace, vice president of client service for business travel management company Carlson Wagonlit Travel. ?There are still enough unknowns about the European crisis that there isn?t an immediate need to react.?

Should the GBTA?s predictions become a reality, Hace goes on to cite previous setbacks in the business travel industry, such as the Sept. 11 attacks and the 2010 volcanic ash eruptions in Iceland, as prime examples of how the system has been able to calibrate itself even in moments of crisis. ?I think as an industry we have an infrastructure of people and talent to address whatever the need might be on behalf our client, whether it?s an immediate security situation or a more long-term economic situation,? he says.

Although the GBTA?s findings do indeed portray quite the extreme worst-case scenario, McCormick?s urge for business owners and travel agents to err on the side of caution is justifiable given the volatile economic climate in Europe. He says, ?We certainly don?t want to be the bearer of bad news, but it?s one of the those situations now where we have to watch it very closely because it could have a very dramatic impact on business travel and business in general.?

Source: http://www.financialeyesandears.com/2012/02/19/euro-debt-crisis-could-cripple-u-s-business-travel/

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